For hoodias, very bright lighting with several hours of direct sun in the morning or evening is used. South, southeast, and southwest windows are suitable, and after winter the plant is gradually acclimated to direct sun to prevent burns on the stems. With insufficient light, shoots stretch out, become softer, colour poorly, and are more easily affected by rot.
During the active season, a temperature of 24-32 °C (75-90 °F) is maintained; with dry air and good ventilation, the plant tolerates higher values. Overwintering is carried out in the brightest possible spot at 10-15 °C (50-59 °F) and kept almost dry. The minimum for a container plant is preferably kept no lower than 8-10 °C (46-50 °F), as cold dampness quickly damages the roots and stem bases.
Watering is carried out rarely, only after complete drying out of the substrate. In summer, the plant is watered moderately, usually once every 10-20 days depending on temperature, pot size, and soil composition. In winter with cool keeping, watering is almost discontinued or carried out minimally once every 4-6 weeks. Soft, warm water is used without stagnation in the saucer, and moisture entering the base of the dense clump is undesirable.
For planting, a very loose mineral substrate is used, dominated by coarse sand, pumice, lava grit, fine gravel, perlite, and a small amount of lean leaf mold. High drainage is necessarily placed at the bottom, and pots are chosen shallow or medium in depth, stable, with wide holes for water drainage. Repotting is carried out in spring, usually once every 2-3 years, with mandatory dry keeping of the plant for several days after repotting.
Fertilizer is applied only during the period of active growth once every 4-6 weeks with a weak solution of fertilizer for cacti and succulents with reduced nitrogen content. Pruning is usually not performed; only dried or damaged shoots are removed. Taking cuttings is possible, but cut surfaces must dry for several days until a dense callus forms, and rooting is carried out only in dry mineral material with very careful moisturizing.