Mammillaria is a large genus of low-growing succulent plants in the cactus family (Cactaceae), comprising about 170–200 species distributed primarily in Mexico, as well as in the southern United States, Central America, the Caribbean region, and northern South America. In nature, members of the genus occur in deserts, semi-deserts, dry scrublands, tropical deciduous forests, on limestone slopes, stony plains, and in mountainous areas with bright sun and well-drained soils.
The plants typically develop as solitary or clustering globular, flattened-globular, cylindrical, or short-columnar cacti. Instead of ribs, they bear individual tubercles, or tuberosities, atop which areoles with radial and central spines are located. In many species, wool, bristles, buds, flowers, and fruits develop in the axils between tubercles.
Flowers typically form in a ring near the stem apex and can be white, cream, yellow, pink, red, or purple. After pollination, elongated or club-shaped fruits develop, often red or pink, containing tiny brown or black seeds with a pitted or reticulated surface.
Mammillaria spinosissima 'Un Pico' is a stable genetic mutation in which each areole produces only a single long spine.